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Ipamorelin

Ipamorelin: Potent New Peptide For Building More Muscle

 

Dear Friend and Fellow Athlete,

Ipamorelin is a fascinating new muscle building discovery that is getting a lot of attention in the bodybuilding world. Like the GHRP-6 peptide (growth hormone releasing hexapeptide), it is a synthetic peptide that has powerful Growth Hormone releasing properties. And these GH releasing properties are what is of interest to athletes and bodybuilders since they can make a tremendous difference in the amount of muscle you can grow and how quickly you burn fat. Both Ipamorelin and GHRP-6 as well as numerous other peptides and research chemicals can be found at unique-lab

Whereas GHRP-6 is a hexapeptide, Ipamorelin is a penta-peptide. (Aib-His-D-2-Nal-D- Phe-Lys-NH2) And, the strength it displays may very well make regular old Growth Hormone (GH) obsolete. But what athletes and bodybuilders really want to know is what is this wonder peptide capable of doing, how is it used, and how does it compare to the other GHRP peptides?

Athletes are taking Ipamorelin in a 200mcg -300mcg dosage, two or three times daily, using a tiny insulin needle to inject. They usually start with the lower dose since side effects can include headaches or what feels like a head-rush. Ipamorelin can be taken at anytime but taking it about 30-45 minutes before a workout would seem ideal because of the pulse in Growth Hormone (GH) it creates allowing for maximum growth.

Studies on the effects of Ipamorelin on bone growth, body weight, and GH release showed some interesting conclusions.

In one experiment, various doses were administered over the course of 15 days to test the group's reactions.

There was a distinct and dose-dependent effect on body weight gain however, the treatment group did not show a change in total IGF-I levels. Nor did the treatment group produce serum markers of bone development. For example, the number of cells in the wide portion of the tibia (the shinbone) did not change significantly. This is a good thing because it suggests muscle growth with less potential for deformity of bone or cartilage.

The reaction of the pituitary to an aggressive i.v. dose of Ipamorelin showed that plasma GH levels were notably reduced whereas they were unchanged after a comparable dose of GHRH. This is actually a good thing as it suggests that Ipamorelin may not decrease your body's natural GH production - further demonstrating that Ipamorelin is a selective GH releaser.

Unlike GHRP-6, Ipamorelin does not induce hunger making it advantageous to those on a restricted calorie diet. And obviously, Ipamorelin's side-effects are enhanced when combined with anabolic steroids since they too influence Growth Hormone/Insulin Growth Factor release and production.

In another study in rats, Ipamorelin released GH from rat pituitary cells as effectively as GHRP-6.

Another document states that in healthy swine, Ipamorelin released GH with a consistency that is very comparable to GHRP-6. Also noteworthy was that none of the GH releasers tested affected FSH, LH, PRL or TSH blood serum plasma levels.

Ipamorelin in theory may increase Acetylchloine or Cortisol when used in higher dosages. However, and increase in Acetylchloine or Cortisol is even more likely with GHRP-2 and GHRP-6. In fact, in the case of Ipamorelin, there was little to no rise in Acetylcholine and Cortisol blood plasma levels even at injections more than 200 times higher than the effective dosage for comparable GH release.

This clearly proves that Ipamorelin is the first successful GHRP receptor agonist or chemical that binds to a receptor of a cell and triggers a response by that cell with a specific selectivity for the promotion of GH release by itself.

Another advantage to Ipamorelin is that it doesn't cause sudden spikes in prolactin or cortisol as does GHRP-2 and GHRP-6. Ipamorelin is slower in its delivery unlike GHRP's which spike GH levels at a more rapid rate. The slower release is more natural and has a more sustained effect.

All in all it looks as if Ipamorelin is the new wave in GH releasing peptides. It appear to be more potent, longer lasting and potentially safer to use in the long run. More studies are being conducted all the time but as it stands, Ipamorelin looks like a serious contender in the arsenal of anabolic advancement.

Both Ipamorelin and GHRP-6 as well as numerous other peptides and research chemicals can be found at unique-lab

Here's some links where you can discuss Ipamorelin on the Elite Fitness Forums.

HEXARLINE

Hexarelin

Hexarelin (HEX) is a peptide GH secretagogue, structurally similar to GHRP-6,  in the growth factor family which stimulates the release of growth hormone (GH).   It can be used medically to treat GH deficiency.  

Background

Although relatively new, Hexarelin is becoming a popular choice as a performance enhancement drug. Hexarelin is currently available from several research companies.

Action

Due to Hexarelin’s ability to increase secretion of natural Growth Hormone, most of its effects are similar to those of synthetic GH, although to a slightly lesser extent.  Effects of its use include:  increase in strength, growth of new muscle fibers, increase in the size of already existing muscle fibers, neural protection, joint rejuvenation, protection and healing.  Also, the GH receptors in adipose (fat) tissue allow for potential fat reduction with Hexarelin use.  The increase of circulating GH through Hexarelin use causes levels of Insulin-Like Growth Factor (IGF-1) to rise in the liver.  IGF-1 is the prime cause of muscle growth in response to GH stimulation.

There is no appetite boost with Hexarelin use (as opposed to GHRP-6’s extreme appetite increase) due to its inability to drastically increase Ghrelin levels that are responsible for added hunger and quicker gastric emptying.

Technical Data

In studies where Hexarelin was injected subcutaneously, Growth Hormone, measured through plasma concentrations, increased significantly and within thirty minutes of injection.  GH levels decreased back to normal around four hours post injection (1).  The GH increase, has been found to be effective up to 2mg/kg, any further increase in dose was found to be ineffective in causing a GH response (2).

Results showed that Hexarelin’s effect on GH stimulation tapered between weeks 4 through 16.  Separating cycles by 4 week off periods, avoided the negative feedback loop and the next cycle of Hexarelin produced the same level of results as the first cycle (3).

User Notes

I used Hexarelin awhile back, at a dose of about 200mcg/day, and found it to be very good for healing my injuries, burning a bit of fat, and helped me gain a bit of muscle.

I also have a couple of friends who are powerlifters, and they were able to use Hexarelin to heal an old Pec injury and train pain free while on it. My bodybuilder friends (yes, not only do I have friends, but some are actually bodybuilders) have said that 400 mcg/day of Hexarelin gave them similar results to low doses of GH (maybe 1-2 iu/day would be a good equivalent).

Overall, Hexarelin is a good all purpose anabolic. Also,  since we know that IGF and GH use produces a shutdown of your endogenous levels of those hormones, Hexarelin also seems very useful for “GH-PCT” or “IGF-PCT”, as it can help restore your natural levels of those hormones after a cycle of them.

References

  1. Imbimbo, B.P., et. al Growth hormone-releasing activity of hexarelin in humans. A dose-response study.Eur J Clin Pharmacol. 1994;46(5):421-5.
  2. Imbimbo, B.P., et. al Growth hormone-releasing activity of hexarelin in humans. A dose-response study.Eur J Clin Pharmacol. 1994;46(5):421-5.
  3. Rahim, A., Shalet, SM Does desensitization to hexarelin occur? Growth Horm IGF Res. 1998 Apr;8 Suppl B:141-3.

MGF

 

 

 

Mechano Growth Factor

Quick Overview

MGF is derived from IGF-I but its sequence differs from the systemic IGF-I produced by the liver. MGF is expressed by mechanically overloaded muscle and is involved in tissue repair and adaptation. It is expressed as a pulse following muscle damage and is apparently involved in the activation of muscle satellite (stem) cells. These donate nuclei to the muscle fibres that are required for repair and for the hypertrophy processes which may have similar regulatory mechanisms


Description

The C-terminal peptide MGF, an alternatively spliced variant IGF-1, was found to function independently from the rest of the molecule. At any rate, IGF-I exists in multiple isoforms (tissue-specific proteins of functional and structural similarity). One isoform, which differs from the systemic or liver type, happens to be particularly sensitive to mechanical signals such as the gamut of exercise overload. MGF is a local splice variant of IGF-I produced by damaged or loaded skeletal muscle. The physiological function of MGF was studied using an in vitro cell model. Unlike mature IGF-I, the distinct E domain of MGF inhibits terminal differentiation whilst increasing myoblast proliferation. Blocking the IGF-I receptor with a specific antibody indicated that the function of MGF E domain is mediated via a different receptor. The results provide a basis for localized tissue adaptation and helps explain why loss of muscle mass occurs in the elderly and in dystrophic muscle in which MGF production is markedly affected.

 

 

 

HCG

Human Chorionic Gonadotrophin

Quick Overview

Active Life: 64 hours
Drug Class: Leutenizing Hormone (LH) - Gonadotropin
Average Dose: debatable
Acne: Yes
Water Retention: Yes
High Blood Pressure: Yes
Liver Toxic: No
Aromatization: No, but it will raise testosterone levels and increased aromatization may occur.

Description

stimulation brought forth by administration of HCG can likewise cause the testicles to rapidly return to their normal size and level of activity. We are not simply looking for it to fix the problem however, as the resulting high testosterone level can itself trigger negative feedback inhibition at the hypothalamus. Estrogen production is also heightened with the use of HCG, due to its ability to increase aromatase activity in the Leydig's cells. This is due to the main action of HCG, namely the increase of cycIicAMP (a secondary messenger that regulates cellular activity). When stimulated by HCG, the ability of the testes to aromatize androgens could potentially be heightened several times greater than normal. This also may inhibit testosterone production, so we therefore use HCG only as a quick shock to the testes. The usual protocol is to inject 1500-3000 I.U. every 4th or 5th day, for a duration usually no longer than 2 or 3 weeks. If used for too long or at too high a dose, the drug may actually function to desensitize the Leydig's cells to luteinizing hormone, further hindering a return to homeostasis. Timing the initial dose is also very crucial. If your were coming off a cycle of Sustanon for example, testosterone levels in your blood will likely stay elevated for at least 3 to 4 weeks after your last injection. Taking HCG on the day of your last shot would therefore be useless. Instead one would want to calculate the last week in which androgen levels are likely to be above normal, and begin ancillary drug therapy at this point. In this case HCG would be started around the third or fourth week. Likewise, after ending a cycle of Dianabol (an oral) your blood levels will be sub normal after the third day. Here you may want to begin HCG therapy a few days before your last intake of tablets, giving it a few days to take effect. One would also want to give some thought to the level of suppression that the cycle might have brought about. After an 8 week cycle of Equipoise for example, 1500-2500 I.U. would likely be a sufficient initial dosage. The lower amount of hormonal suppression one associates with this drug would probably not require much more. On the other hand, 750-1000mg of Sustanon per week might incline the user to inject a much larger HCG dose, perhaps as much as 5000 I.U. for the opening application. It may thereafter also be a good idea to reduce the dosage on subsequent shots, so as to step down the intake of HCG during the two or three weeks of intake.


GHRP-6

Growth Hormone Releasing Peptide

Quick Overview

Growth hormone releasing hexapeptide (GHRP6) is one of several synthetic met-enkephalin analogs that include unnatural D-amino acids, were developed for their growth hormone (GH) releasing activity and are called GH secretagogues. They lack opioid activity but are potent stimulators of GH release. These secretagogues are distinct from growth hormone releasing hormone (GHRH) in that they share no sequence relation and derive their function through action at a completely different receptor. This receptor was first called the GH secretagogue receptor, but now we know that the hormone ghrelin is this receptor's natural endogenous ligand and that these GH secetagouges act as synthetic mimetics of ghrelin.

Description

GHRP-6, other secretagogues and ghrelin stimulate the anterior pituitary gland causing an increase in GH release. When natural GH secretion has been inhibited by long term abuse of synthetic GH, GHRP-6 may help to re-stimulate the natural production of GH. GHRP-6 may also affect the central nervous system by protecting neurons as well as increasing strength in a way very similar to the way certain steroids in the Dihydrotestosterone family do.

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