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Proviron (Mesterolon)

Mesterolone

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Mesterolone
Mesterolone.svg
Systematic (IUPAC) name
1 alpha-methyl-17 beta-hydroxy-5 alpha-androstan-3-one
Clinical data
AHFS/Drugs.com International Drug Names
Legal status Prescription Only (AU)
Pharmacokinetic data
Metabolism Liver
Identifiers
CAS number 1424-00-6
ATC code G03BB01
PubChem CID 15020
ChemSpider 14296 Yes
UNII 0SRQ75X9I9 Yes
KEGG D04947 Yes
ChEMBL CHEMBL258918 Yes
Chemical data
Formula C20H32O2
Mol. mass 304.467 g/mol
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Mesterolone is an orally applicable androgen, and DHT derivative. It is sold under the brand name Proviron (as Provironum in Asia-Pacific region), by Bayer Schering Pharma (earlier by Schering). In the late 70's and early 80's it was used with some success in controlled studies of men suffering from various forms of depression. Mesterolone is a relatively weak androgen and rarely used for replacement therapies.[1]

Trials

In one randomized, double-blind 4-week trial, 38 dysthymic men were administered 75 mg daily. Itil & Colleagues reported an improvement of symptoms which included anxiety, lack of drive and desire. Next, they administered a high dose (450 mg/day) or placebo in a 6-week randomized trial of 52 men with a mean age of 40 years, suffering from dysthymia, unipolar and bipolar depression. Both the mesterolone and placebo groups improved significantly and there were no statistically significant differences between the two groups. In this series of studies mesterolone lead to a significant decrease in LH and testosterone levels. This is probably as a result of the extremely high dose used. In another, 100 mg mesterolone cipionate was administered twice monthly. With regards to plasma T levels, there was no difference between the treated vs untreated group, and baseline LH levels were minimally affected.[2]

Bodybuilding

Mesterolone had seen widespread use in bodybuilding primarily for antiestrogenic activity in anabolic steroid stacks but such use has declined after introduction of aromatase inhibitors and SERMs. Most significant benefits of current Mesterolone use are considered to be maintaining libido off-cycle and also relatively and temporarily improving vascularity.[3]

References

  1. Jump up ^ Nieschlag E, Behre HM, Bouchard P, et al. (2004). "Testosterone replacement therapy: current trends and future directions". Hum. Reprod. Update 10 (5): 409–19. doi:10.1093/humupd/dmh035. PMID 15297434.
  2. Jump up ^ Kövary PM, Lenau H, Niermann H, Zierden E, Wagner H (May 1977). "Testosterone levels and gonadotrophins in Klinefelter's patients treated with injections of mesterolone cipionate". Arch Dermatol Res 258 (3): 289–94. PMID 883846.
  3. Jump up ^ Meso-RX Steroid Profiles - Proviron (Mesterolone)

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